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Page 1
Cloning of aroG, the gene coding for phospho-2-keto-3-deoxy-heptonate aldolase(phe), in Escherichia coli K-12, and subcloning of the aroG promoter and operator in a promoter-detecting plasmid.
Davies WD, Pittard J, Davidson BE. Davies WD, et al. Gene. 1985;33(3):323-31. doi: 10.1016/0378-1119(85)90240-9. Gene. 1985. PMID: 2861143
Defective transducing phages carrying aroG, the structural gene for phenylalanine (phe)-inhibitable phospho-2-keto-heptonate aldolase (EC 4.1.2.15; previously known as 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase[phe]), have been isolated, and DNA from two of thes …
Defective transducing phages carrying aroG, the structural gene for phenylalanine (phe)-inhibitable phospho-2-keto-heptonate aldolase …
Identification of the promoter, operator, and 5' and 3' ends of the mRNA of the Escherichia coli K-12 gene aroG.
Baseggio N, Davies WD, Davidson BE. Baseggio N, et al. J Bacteriol. 1990 May;172(5):2547-57. doi: 10.1128/jb.172.5.2547-2557.1990. J Bacteriol. 1990. PMID: 1970563 Free PMC article.
In these experiments, a region of up to 80 base pairs (bp) was protected by the binding of RNA polymerase. The location of the aroG operator was also identified in both strands of the DNA by in vitro DNase I footprinting with pure TyrR. ...The effects of the mutatio …
In these experiments, a region of up to 80 base pairs (bp) was protected by the binding of RNA polymerase. The location of the aroG o …
Metabolic engineering of Escherichia coli for the enhanced production of l-tyrosine.
Kim B, Binkley R, Kim HU, Lee SY. Kim B, et al. Biotechnol Bioeng. 2018 Oct;115(10):2554-2564. doi: 10.1002/bit.26797. Epub 2018 Aug 1. Biotechnol Bioeng. 2018. PMID: 30019750
Also, blocking cellular uptake of l-tyrosine by knocking out tyrosine transporters was examined with respect to l-tyrosine production. Using feedback-resistant aroG and tyrA genes (aroG(fbr) and tyrA(fbr) hereafter) as initial overexpression targets, which encode 3- …
Also, blocking cellular uptake of l-tyrosine by knocking out tyrosine transporters was examined with respect to l-tyrosine production. Using …
Analysis of an Escherichia coli mutant TyrR protein with impaired capacity for tyrosine-mediated repression, but still able to activate at sigma 70 promoters.
Kwok T, Yang J, Pittard AJ, Wilson TJ, Davidson BE. Kwok T, et al. Mol Microbiol. 1995 Aug;17(3):471-81. doi: 10.1111/j.1365-2958.1995.mmi_17030471.x. Mol Microbiol. 1995. PMID: 8559066
The TyrR central domain is homologous with NtrC and some other bacterial regulatory proteins, although TyrR regulates sigma 70, not sigma 54, promoters. We isolated a central domain TyrR mutant (TyrR E274Q) by substitution of a normally conserved amino …
The TyrR central domain is homologous with NtrC and some other bacterial regulatory proteins, although TyrR regulates sigma 70 …
Metabolic engineering of Escherichia coli for the production of an antifouling agent zosteric acid.
Zhang P, Gao J, Zhang H, Wang Y, Liu Z, Lee SY, Mao X. Zhang P, et al. Metab Eng. 2023 Mar;76:247-259. doi: 10.1016/j.ymben.2023.02.007. Epub 2023 Feb 22. Metab Eng. 2023. PMID: 36822462
Co-overexpression of the genes encoding tyrosine ammonia-lyase, sulfotransferase 1A1, ATP sulfurylase, and adenosine 5'-phosphosulfate kinase constructed ZA producing strain with enhanced PAPS supply. Second, the feedback-resistant forms of aroG and tyrA genes (encoding 3- …
Co-overexpression of the genes encoding tyrosine ammonia-lyase, sulfotransferase 1A1, ATP sulfurylase, and adenosine 5'-phosphosulfate kinas …
Artificial cell factory design for shikimate production in Escherichia coli.
Lee HN, Seo SY, Kim HJ, Park JH, Park E, Choi SS, Lee SJ, Kim ES. Lee HN, et al. J Ind Microbiol Biotechnol. 2021 Dec 23;48(9-10):kuab043. doi: 10.1093/jimb/kuab043. J Ind Microbiol Biotechnol. 2021. PMID: 34227672 Free PMC article.
The genes with negative effects on shikimate biosynthesis, including tyrR, ptsG, and pykA, were disrupted. In contrast, several shikimate biosynthetic pathway genes, including aroB, aroD, aroF, aroG, and aroE, were overexpressed to maximize the glucose uptake and in …
The genes with negative effects on shikimate biosynthesis, including tyrR, ptsG, and pykA, were disrupted. In contrast, several shiki …
Fermentation and Metabolic Pathway Optimization to De Novo Synthesize (2S)-Naringenin in Escherichia coli.
Zhou S, Hao T, Zhou J. Zhou S, et al. J Microbiol Biotechnol. 2020 Oct 28;30(10):1574-1582. doi: 10.4014/jmb.2008.08005. J Microbiol Biotechnol. 2020. PMID: 32830192 Free PMC article.
The tyrosine synthesis pathway was enhanced by overexpressing feedback inhibition-resistant genes (aroG(fbr) and tyrA(fbr)) and knocking out a repressor gene (tyrR). ...
The tyrosine synthesis pathway was enhanced by overexpressing feedback inhibition-resistant genes (aroG(fbr) and tyrA(fbr)) and knock …
Chromosome Engineering To Generate Plasmid-Free Phenylalanine- and Tyrosine-Overproducing Escherichia coli Strains That Can Be Applied in the Generation of Aromatic-Compound-Producing Bacteria.
Koma D, Kishida T, Yoshida E, Ohashi H, Yamanaka H, Moriyoshi K, Nagamori E, Ohmoto T. Koma D, et al. Appl Environ Microbiol. 2020 Jul 2;86(14):e00525-20. doi: 10.1128/AEM.00525-20. Print 2020 Jul 2. Appl Environ Microbiol. 2020. PMID: 32414798 Free PMC article.
Integration into the E. coli chromosome of two central metabolic pathway genes (ppsA and tktA) and eight shikimate pathway genes (aroA, aroB, aroC, aroD, aroE, aroG(fbr) , aroL, and pheA(fbr) ), controlled by the T7lac promoter, resulted in excellent titers and yields of p …
Integration into the E. coli chromosome of two central metabolic pathway genes (ppsA and tktA) and eight shikimate pathway genes (aroA, aroB …
Designing an Escherichia coli Strain for Phenylalanine Overproduction by Metabolic Engineering.
Tyagi N, Saini D, Guleria R, Mukherjee KJ. Tyagi N, et al. Mol Biotechnol. 2017 May;59(4-5):168-178. doi: 10.1007/s12033-017-9999-5. Mol Biotechnol. 2017. PMID: 28374116
In order to demonstrate the importance of these global regulators, we first removed the pathway-specific regulators using all possible combinations of gene knockouts and knockins. We found that genes like aroG (fbr) performed best individually as well as in combination wit …
In order to demonstrate the importance of these global regulators, we first removed the pathway-specific regulators using all possible combi …
Cell Factory Design and Culture Process Optimization for Dehydroshikimate Biosynthesis in Escherichia coli.
Choi SS, Seo SY, Park SO, Lee HN, Song JS, Kim JY, Park JH, Kim S, Lee SJ, Chun GT, Kim ES. Choi SS, et al. Front Bioeng Biotechnol. 2019 Oct 9;7:241. doi: 10.3389/fbioe.2019.00241. eCollection 2019. Front Bioeng Biotechnol. 2019. PMID: 31649923 Free PMC article.
First, the genes showing negative effects on DHS accumulation in E. coli, such as tyrR (tyrosine dependent transcriptional regulator), ptsG (glucose specific sugar: phosphoenolpyruvate phosphotransferase), and pykA (pyruvate kinase 2), were disrupted. In addition, the gene …
First, the genes showing negative effects on DHS accumulation in E. coli, such as tyrR (tyrosine dependent transcriptional regulator) …
22 results